中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (3): 803-804.doi: 10.4103/NRR.NRR-D-23-02057

• 观点:退行性病与再生 • 上一篇    下一篇

反义寡核苷酸为tau病的治疗前景提供了乐观

  

  • 出版日期:2025-03-15 发布日期:2024-06-26

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

Glenn A. Harris*, Lauren R. Hirschfeld   

  1. Rainwater Charitable Foundation, Fort Worth, TX, USA
  • Online:2025-03-15 Published:2024-06-26
  • Contact: Glenn A. Harris, PhD, gharris@rainwatercf.org.
  • Supported by:
    This work was supported by the Rainwater Charitable Foundation.

摘要: https://orcid.org/0000-0002-6867-391X (Glenn A. Harris)

Abstract: Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene (MAPT) and can be classified as either 3-repeat (3R) or 4-repeat (4R) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene. Tauopathies are subdivided into primary tauopathies and secondary tauopathies (Chung et al., 2021). Primary tauopathies involve tau protein aggregation and tangling as a predominant feature. Primary tauopathies exhibit clinical heterogeneity, and their neuropathological features guide definitive diagnosis. Examples of primary tauopathies include progressive supranuclear palsy, frontotemporal dementia, Pick’s disease, chronic traumatic encephalopathy, corticobasal degeneration, primary age-related tauopathy, aging-related tau astrogliopathy, globular glia tauopathy, tangle-only dementia, and argyrophilic grain disease. Secondary tauopathies, such as Alzheimer’s disease (AD) and Down’s syndrome, feature tau protein aggregates coexisting with other protein abnormalities.