中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (4): 1087-1089.doi: 10.4103/NRR.NRR-D-24-00066

• 观点:退行性病与再生 • 上一篇    下一篇

外周淀粉样蛋白-β聚集体在阿尔茨海默病中的作用:机制、诊断和治疗意义

  


  • 出版日期:2025-04-15 发布日期:2024-07-01

Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications

Nazaret Gamez, Rodrigo Morales*   

  1. Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX, USA (Gamez N, Morales R)
    Centro Integrativo de Biologia y Quimica Aplicada (CIBQA), Universidad Bernardo O’Higgins, Santiago, Chile (Morales R)

  • Online:2025-04-15 Published:2024-07-01
  • Contact: Rodrigo Morales, PhD, Rodrigo.MoralesLoyola@uth.tmc.edu.
  • Supported by:
    This work was supported by grants from NIH (RF1AG072491 and R01AI132695) to RM.

摘要: https://orcid.org/0000-0001-7766-5770 (Rodrigo Morales)

Abstract: Compelling evidence demonstrates that the levels of peripheral amyloid-β (Aβ) fluctuate in Alzheimer’s disease (AD) patients. Moreover, Aβ deposits have been identified in peripheral tissues. However, the relevance of peripheral Aβ (misfolded or not) in pathological situations, and the temporal appearance of these pathological fluctuations, are not well understood. The presence of misfolded Aβ in peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated protein. The latter is supported by multiple reports demonstrating that Aβ misfolding can be transmitted between humans and experimental animals through multiple routes of exposure. In this mini-review, we discuss the potential implications of peripheral, diseaseassociated Aβ in disease mechanisms, as well as in diagnostic and therapeutic approaches.