中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (8): 2317-2318.doi: 10.4103/NRR.NRR-D-24-00335

• 观点:退行性病与再生 • 上一篇    下一篇

额颞叶变性患者血清纤溶酶原激活物抑制物-1水平升高的机制

  

  • 出版日期:2025-08-15 发布日期:2024-12-13

Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

Francesco Angelucci* , Jakub Hort   

  1. Memory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic (Angelucci F, Hort J) International Clinical Research Centre, St. Anne’s University Hospital, Brno, Czech Republic (Hort J)
  • Online:2025-08-15 Published:2024-12-13
  • Contact: Francesco Angelucci, PhD, francesco.angelucci@lfmotol.cuni.cz or fangelucci@hotmail.com.
  • Supported by:
    This work was funded by the project National Institute for Neurological Research (Programme EXCELES, ID Project No. LX22NPO5107) and by TEAMING: 857560 (EU) and CZ.02.1.01/0.0/0.0/17 _043/0009632 (CZ) (to FA and JH).

摘要: https://orcid.org/0000-0002-5956-5925 (Francesco Angelucci)

Abstract: Frontotemporal lobar degeneration (FTLD) is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the brain. This pathology involves a series of cognitive, behavioral, and neurological symptoms that influence personality, decision-making ability, and language. Although it has been recognized for decades, its exact etiology and underlying mechanisms are still not fully understood. In recent years, however, there has been growing interest in research into factors that may contribute to the development and progression of FTLD. Among these, in a recent study, we observed that serum levels of an inhibitor of plasmin synthesis, the plasminogen activator inhibitor-1 (PAI-1), are elevated in FTLD patients with dementia as compared to healthy controls (Angelucci et al., 2024). Furthermore, we observed a negative correlation between PAI-1 serum levels and disease severity measured by MMSE score.