中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (10): 2917-2918.doi: 10.4103/NRR.NRR-D-24-00646

• 观点:退行性病与再生 • 上一篇    下一篇

神经胶质细胞在帕金森病中产生区域特异性神经炎症反应和吞噬作用的互补作用

  

  • 出版日期:2025-10-15 发布日期:2025-02-08

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

Leyre Ayerra, Maria S. Aymerich*   

  1. Universidad de Navarra, Facultad de Ciencias, Departamento de Bioquímica y Genética, Pamplona, Spain (Ayerra L, Aymerich MS) CIMA-Universidad de Navarra, Pamplona, Spain (Ayerra L, Aymerich MS) IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain (Aymerich MS)
  • Online:2025-10-15 Published:2025-02-08
  • Contact: Maria S. Aymerich, PhD, maymerich@unav.es
  • Supported by:
    This work was supported by the Spanish Government (ISCIII-FEDER) PI20/01063, by Navarra Government (PC 060-061 and PC 192-193), and Fundación Gangoiti (to MSA). LA was funded by FPU19/03255.

摘要: https://orcid.org/0000-0001-9750-1538 (Maria S. Aymerich) https://orcid.org/0000-0001-9696-1751 (Leyre Ayerra)

Abstract: N e u ro i n f l a m m a t i o n i s a s s o c i a te d w i t h Parkinson’s disease: Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease (PD), a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons. Neuroinflammation has long been considered a mere consequence of neuronal loss, but whether it promotes PD or is a key player in disease progression remains to be determined. Human leukocyte antigen, also known as major histocompatibility complex class II (MHCII), is expressed on all antigenpresenting cells of the immune system including microglia and central nervous system resident macrophages, and interestingly, its expression is increased in post-mortem PD samples (McGeer, 1988; Imamura, 2003). The strongest evidence for a link between the immune system and PD comes from genome-wide association studies, which have identified several polymorphisms in human leukocyte antigen-DR that are associated with an increased risk of idiopathic PD (Harms, 2023). Neuroinflammation is a complex and dynamic process that requires a cross-talk between glial and peripheral immune cells. Understanding these interactions is crucial for developing immunomodulatory interventions that could delay disease progression.