中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (12): 3519-3520.doi: 10.4103/NRR.NRR-D-24-00956

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

轴突再生中的自噬调节和功能:秀丽隐杆线虫带来的新见解

  

  • 出版日期:2025-12-15 发布日期:2025-03-15

Autophagy regulation and function in axon regeneration: new insights from Caenorhabditis elegans

Su-Hyuk Ko, Lizhen Chen*   

  1. Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA (Ko SH, Chen L) Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA (Ko SH, Chen L) Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, USA (Ko SH, Chen L)
  • Online:2025-12-15 Published:2025-03-15
  • Contact: Lizhen Chen, PhD, ChenL7@uthscsa.edu.

摘要: https://orcid.org/0000-0002-5008-0083 (Su-Hyuk Ko) https://orcid.org/0000-0001-5313-7340 (Lizhen Chen) 

Abstract: Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins, which is essential for the growth and repair of axons. In response to axonal injury, autophagy is upregulated to facilitate the removal of cellular debris and support the recycling of essential components needed for regeneration. This process, known as bulk autophagy, not only helps mitigate damage but also provides the necessary building blocks for axonal repair. Moreover, our previous work suggests that in addition to bulk autophagy, selective autophagy can specifically target and degrade inhibitors of axon regeneration, thereby promoting axon regrowth (Ko et al., 2020). Understanding the regulation and function of autophagy in axon regeneration could provide valuable insights for developing therapeutic strategies to target autophagy in neurodegenerative diseases and nerve injuries.