中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (1): 296-297.doi: 10.4103/NRR.NRR-D-24-01043

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

嗅鞘神经胶质细胞重编程诱导神经元:修复脊髓损伤的可行方法

  

  • 出版日期:2026-01-15 发布日期:2025-04-23

Reprogramming induced neurons from olfactory ensheathing glial cells: A feasible approach for spinal cord injury repair

Javier Sierra* , María Portela-Lomba, Diana Simón, M. Teresa Moreno-Flores*   

  1. Facultad de Medicina, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain (Sierra J) Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA (Portela-Lomba M) Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain (Simón D) Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain (Moreno-Flores MT)
  • Online:2026-01-15 Published:2025-04-23
  • Contact: Javier Sierra, PhD, j.sierra.prof@ufv.es; M. Teresa Moreno-Flores, PhD, mteresa.moreno@uam.es.
  • Supported by:
    This work was financially supported by Ministerio de Ciencia e Innovación projects SAF2017-82736- C2-1-R to MTMF, in Universidad Autónoma de Madrid and by Fundación Universidad Francisco de Vitoria to JS. MPL received a predoctoral scholarship from Fundación Universidad Francisco de Vitoria and financial support from a 6-month contract from Universidad Autónoma de Madrid and a 3-month contract from the School of Medicine of Universidad Francisco de Vitoria.

摘要: https://orcid.org/0000-0003-0563-4179 (Javier Sierra) https://orcid.org/0000-0002-8494-8143 (M. Teresa Moreno-Flores)

Abstract: Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury (SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons. This is due to several causes: (i) intrinsic neuronal deficits in the expression of genes involved in axon regrowth/regeneration; (ii) the presence of inhibitory factors as well as the lack of trophic factors for neuroprotection and regeneration in the affected area; and (iii) a physical impediment due to the formation of the glial scar (Varadarajan et al., 2022).