中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (2): 659-660.doi: 10.4103/NRR.NRR-D-24-01025

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

线粒体功能障碍与髓鞘形成的交集:神经发育障碍中一个被忽视的方面

  

  • 出版日期:2026-02-15 发布日期:2025-05-23

Intersection of mitochondrial dysfunction and myelination: An overlooked aspect in neurodevelopmental disorders

Ariel Nir Sade, Gal Wiener, Boaz Barak*   

  1. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel (Sade AN, Wiener G, Barak B) School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel (Barak B)
  • Online:2026-02-15 Published:2025-05-23
  • Contact: Boaz Barak, PhD, boazba@tauex.tau.ac.il.

摘要: https://orcid.org/0000-0001-9724-4578 (Boaz Barak)

Abstract: Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors, shaping the dynamic landscape of the developing brain. A major component of the developing brain that enables this dynamic is the white matter (WM), known to be affected in neurodevelopmental disorders (NDDs) (Rokach et al., 2024). WM formation is mediated by myelination, a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality (Simons and Trajkovic, 2006). Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function, with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function (Devine and Kittler, 2018; Rojas-Charry et al., 2021). Energy homeostasis in neurons, attributed largely to mitochondrial function, is critical for proper functionality and interactions with oligodendrocytes (OLs), the cells forming myelin in the brain’s WM. We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.