中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 908-922.doi: 10.4103/NRR.NRR-D-24-01638

• 综述:退行性病与再生 • 上一篇    下一篇

多酚和黄酮类化合物对光感受器退行性疾病的神经保护作用

  

  • 出版日期:2026-03-15 发布日期:2025-07-02

Neuroprotection provided by polyphenols and flavonoids in photoreceptor degenerative diseases

Théo Henrique de Lima-Vasconcellos1 , Gabrieli Bovi dos Santos1 , Marília Inês Móvio1 , Giovanna Klemenc Donnici1 , Gabriela Maria Badin1 , Daniele Ribeiro de Araujo2, 3, Alexandre Hiroaki Kihara1, 4, *   

  1. 1 Laboratório de Neurogenética, Universidade Federal do ABC, São Bernardo do Campo, SP, Brasil;  2 Departamento de Biofísica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil;  3 Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP, Brasil;  4 Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brasil
  • Online:2026-03-15 Published:2025-07-02
  • Contact: Alexandre Hiroaki Kihara, PhD, alexandrekihara@gmail.com.
  • Supported by:
    AHK is grateful for grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Brazil, #2020/11667-0) and Universidade Federal do ABC (UFABC, Brazil). The following authors were recipients of fellowships from FAPESP: THLV (#2021/11969-9 and #2024/00828-3), GBS (#2021/14227-3), and GMB (#2024/10858-7). The following authors were recipients of fellowships from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil): MIM (Finance Code 001, #88887.597402/2021-00). The following authors were recipients of fellowships from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil.): GKD (#145164/2024-1), and DRA (#308819/2022-5). The funders had no role in study design, data collection and analysis, decision to publish, or manuscript preparation.

摘要: https://orcid.org/0000-0002-4027-7261 (Alexandre Hiroaki Kihara) 

Abstract: The intricate landscape of neurodegenerative diseases complicates the search for effective therapeutic approaches. Photoreceptor degeneration, the common endpoint in various retinal diseases, including retinitis pigmentosa and age-related macular degeneration, leads to vision loss or blindness. While primary cell death is driven by genetic mutations, oxidative stress, and neuroinflammation, additional mechanisms contribute to disease progression. In retinitis pigmentosa, a multitude of genetic alterations can trigger the degeneration of photoreceptors, while other retinopathies, such as agerelated macular degeneration, are initiated by combinations of environmental factors, such as diet, smoking, and hypertension, with genetic predispositions. Nutraceutical therapies, which blend the principles of nutrition and pharmaceuticals, aim to harness the health benefits of bioactive compounds for therapeutic applications. These compounds generally possess multi-target effects. Polyphenols and flavonoids, secondary plant metabolites abundant in plant-based foods, are known for their antioxidant, neuroprotective, and anti-inflammatory properties. This review focuses on the potential of polyphenols and flavonoids as nutraceuticals to treat neurodegenerative diseases such as retinitis pigmentosa. Furthermore, the importance of developing reliable delivery methods to enhance the bioavailability and therapeutic efficacy of these compounds will be discussed. By combining nutraceuticals with other emerging therapies, such as genetic and cell-based treatments, it is possible to offer a more comprehensive approach to treating retinal degenerative diseases. These advancements could lead to a viable and accessible option, improving the quality of life for patients with retinal diseases.

Key words: flavonoids, neuroinflammation, nutraceutical therapy, oxidative stress, retinitis pigmentosa