中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (3): 1118-1119.doi: 10.4103/NRR.NRR-D-24-01484

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

星形胶质细胞在发育期对γ-氨基丁酸张力调节中的潜在作用

  

  • 出版日期:2026-03-15 发布日期:2025-07-04

Potential role of astrocyte on gamma-aminobutyric acid tone regulation during developmental period

Erva Ozkan, Wuhyun Koh*   

  1. Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea (Ozkan E, Koh W) Department of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea (Ozkan E)
  • Online:2026-03-15 Published:2025-07-04
  • Contact: Wuhyun Koh, PhD, whvankoh@ibs.re.kr.
  • Supported by:
    This work was supported by the Center for Cognition and Sociality, Institute for Basic Science (IBS) (IBS-R001-D2) (to WK).

摘要: https://orcid.org/0000-0002-4398-1094 (Wuhyun Koh)

Abstract: The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions. Gamma-aminobutyric acid (GABA), recognized as a major neurotransmitter, plays a crucial role in coordinating synapse formation, neuronal proliferation, and migration during this time. Notably, recent studies have distinguished two modes of GABA action in the brain: a fast, phasic mode mediated by synaptic GABA release from GABAergic neurons, and a slower, tonic mode resulting from GABA release by non-neuronal cells, particularly astrocytes, which primarily inhibits neuronal activity and synaptic transmission, regulating various cognitive functions (Koh et al., 2023). However, the specific role of tonic GABA effects during the developmental period remains underexplored (Figure 1A). Here, we aim to examine the potential role of astrocytes in regulating GABA tone during development, thereby stimulating further investigation into GABA tone during this critical period.