中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (7): 2950-2951.doi: 10.4103/NRR.NRR-D-25-00318

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

甘氨酸脱羧酶作为 N-甲基-D-天冬氨酸受体功能的新型调节因子:对精神分裂症病理生理学的启示

  

  • 出版日期:2026-07-15 发布日期:2026-03-27

Glycine decarboxylase as a novel regulator of N-methyl-D-aspartate receptor function: Implications for pathophysiology of schizophrenia

Maltesh Kambali*, Uwe Rudolph   

  1. Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA
    Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, USA
    Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA
  • Online:2026-07-15 Published:2026-03-27
  • Contact: Maltesh Kambali, PhD, mkambali@illinois.edu; Uwe Rudolph, MD, urudolph@illinois.edu.
  • Supported by:

摘要: https://orcid.org/0000-0002-7635-5030 (Maltesh Kambali)
https://orcid.org/0000-0001-9396-4746 (Uwe Rudolph)

Abstract: G l u t a m a t e r e c e p t o r s a n d s c h i z o p h r e n i a : Schizophrenia is a chronic mental disorder affecting approximately 1% of the global population, with 70%–80% heritability. It has a multifactorial etiology involving both environmental factors and a complex polygenic genetic architecture. Over the last two decades, large-scale genome-wide approaches revealed contributions of common variants with individually small effect sizes and of rare copy number variants with a large effect size.