中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (6): 2347-2348.doi: 10.4103/NRR.NRR-D-25-00520

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

超越瘫痪:细胞疗法干预脊髓损伤对脑部炎症和认知功能的影响

  

  • 出版日期:2026-06-15 发布日期:2026-04-16

Beyond Paralysis: Impact of Spinal Cord Injury on Brain Inflammation and Cognitive Function through Cell Therapy

Quentin Delarue*, Nicolas Guérout*   

  1. Université Paris Cité, CNRS UMR, Saints-Pères Paris Institute for Neurosciences, Paris, France
  • Online:2026-06-15 Published:2026-04-16
  • Contact: Quentin Delarue, PhD, quentindelarue.rd@gmail.com; Nicolas Guérout, PhD, nicolas.guerout@u-paris.fr.

摘要: https://orcid.org/0009-0008-0486-7310 (Quentin Delarue)
https://orcid.org/0000-0003-0237-4981 (Nicolas Guérout)

Abstract: Traumatic spinal cord injury (SCI) is a pathological condition that impairs both sensorimotor and cognitive functions. While research has long focused on understanding the pathophysiology of SCI and developing treatments, only a few studies have investigated the cellular and molecular consequences that occur in the brain after trauma. From the earliest stages, the injury triggers microglial activation, increased neuronal death, and reduced hippocampal neurogenesis in the dentate gyrus, which in turn leads to cognitive impairments such as deficits in working memory, attention, learning capacity, and the detection and evaluation of stimuli (Li et al., 2020). These effects are a direct consequence of secondary damage following SCI and the onset of neuroinflammation, which can persist chronically.