中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (6): 2351-2352.doi: 10.4103/NRR.NRR-D-25-00182

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

超越凋亡:Annexin-V与髓细胞结合在视网膜细胞凋亡检测成像中的意义

  

  • 出版日期:2026-06-15 发布日期:2026-04-16

Beyond Apoptosis: Implications of Annexin-V binding to Myeloid Cells in DARC Imaging

Kiyoharu J. Miyagishima*, #, Francisco M. Nadal-Nicolás*, #, Wei Li   

  1. Retinal Neurophysiology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA 
  • Online:2026-06-15 Published:2026-04-16
  • Contact: Kiyoharu J. Miyagishima, PhD, kiyoharu.miyagishima@nih.gov; Francisco M. Nadal-Nicolás, PhD, fm.nadalnicolas@um.es.
  • Supported by:
    This work was supported [in part] by the Intramural Research Program of the National Institutes of Health (NIH) (to KJM), and also supported by the Office by the Office of the Assistant Secretary of Defense for Health Affairs and the Defense Health Agency J9, Research and Development Directorate, through the Vision Research Program under Award No. (CDMRPL-18-0-VR180205 to KJM and FMN-N). The contributions of the NIH author(s) were made as part of their official duties as NIH federal employees, are in compliance with agency policy requirements, and are considered Works of the United States Government. However, the findings and conclusions presented in this paper are those of the author(s) and do not necessarily reflect the views of the NIH, the U.S. Department of Health and Human Services, or the U.S. Department of Defense.

摘要: https://orcid.org/0000-0002-9744-3152 (Kiyoharu J. Miyagishima)
https://orcid.org/0000-0003-4121-514X (Francisco M. Nadal-Nicolás)

Abstract: In vivo imaging of neurodegenerative diseases provides valuable insights into disease mechanisms and potential therapeutic interventions. Many ocular diseases are closely linked to neurodegenerative conditions affecting the brain, making the eye a unique and accessible model for studying these disorders. The transparency of eyes allows researchers to monitor disease progression non-invasively, offering a window into neural health. In particular, the retina serves as a critical platform for studying neurodegeneration and exploring therapeutic strategies that may translate across different diseases.