中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3332-3335.doi: 10.4103/NRR.NRR-D-25-00345

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

TPPP3及其家族成员蛋白在神经元疾病中的作用

  

  • 出版日期:2026-08-18 发布日期:2026-04-23

Insights from TPPP3 and its family member proteins in neuronal diseases 

Mishal Rao1, Kun-Che Chang1, 2, 3, *   

  1. 1Department of Ophthalmology, Louis J. Fox Center for Vision Restoration, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; 
    2Department of Neurobiology, Center of Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; 
    3Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
  • Online:2026-08-18 Published:2026-04-23
  • Contact: Kun-Che Chang, PhD, kcchang@pitt.edu.
  • Supported by:
    This work was supported by NIH Core Grants P30-EY008098, the Eye and Ear Foundation of Pittsburgh, and unrestricted grants from Research to Prevent Blindness, New York, NY, USA (to KCC).

摘要: https://orcid.org/0000-0002-0871-5612 (Kun-Che Chang)

Abstract: Tubulin polymerization-promoting protein family member 3 (TPPP3) is a neuronal-specific protein involved in cytoskeletal stability, axonal maintenance, and neuronal survival. Dysregulation of TPPP3 is implicated in neurodegenerative diseases such as Parkinson’s disease and diabetic retinopathy. Unlike TPPP1, which is oligodendrocyte-specific, TPPP3 was reported to primarily promote neuronal regeneration and serve as a therapeutic target for neurodegenerative diseases such as Parkinson’s disease and glaucoma. Beyond the nervous system, TPPP3 has been linked to oncogenesis and tissue regeneration, suggesting potential roles in tumor suppression and wound healing. This review summarizes neuronal functions of TPPP3, therapeutic opportunities, and future research directions. Understanding the molecular mechanisms underlying function of TPPP3 could provide valuable insights into its therapeutic applications in neuroprotection.

Key words: axonal regeneration, glaucoma, microtubule stabilization, neuroprotection, Parkinson’s disease, TPPP3