中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3523-3524.doi: 10.4103/NRR.NRR-D-25-00482

• 观点:退行性病与再生 • 上一篇    下一篇

人工智能在淀粉样变性病预测中的应用


  

  • 出版日期:2026-08-18 发布日期:2026-04-25

Application of Artificial Intelligence for the Prediction of Amyloidoses

Valentin Gonay, Michael P. Dunne*, Andrey V. Kajava*   

  1. CRBM UMR 5237 CNRS, Université Montpellier, Montpellier, France (Gonay V, Kajava AV)
    PROTERA SAS, Paris, France (Gonay V, Dunne MP)
  • Online:2026-08-18 Published:2026-04-25
  • Contact: Michael P. Dunne, PhD, mdunne@proterabio.com; Andrey V. Kajava, PhD, andrey.kajava@crbm.cnrs.fr.
  • Supported by:
    This work was supported in part by a CIFRE PhD fellowship through the “Association Nationale de la Recherche et de la Technologie” (ANRT) program, in collaboration between PROTERA and “Center National de la Recherche Scientifique” (CNRS) to VG, by EU COST Action ML4NGP CA21160 to VG and AVK, by the Fondation pour la Recherche Médicale (grant MND202310017898) to AVK and by the AFM-Téléthon (grant n° 28988) to AVK.

摘要: https://orcid.org/0000-0001-7517-3860 (Michael P. Dunne)
https://orcid.org/0000-0002-2342-6886 (Andrey V. Kajava)

Abstract: Amyloidosis is a group of diseases caused by the abnormal accumulation of amyloid fibrils (misfolded protein aggregates) in various human tissues. These amyloid deposits can interfere with normal organ function and lead to severe health issues. Amyloid plaque formation in the brain is linked to neurodegenerative diseases, including Tau and Aβ plaques in Alzheimer ’s disease, α-synuclein plaques in Parkinson’s disease, and huntingtin plaques in Huntington’s disease. Although this condition is typically associated with aging, certain mutations in amyloid-forming proteins can trigger early-onset amyloidosis (Hatami et al., 2017). Given its progressive and lifethreatening nature