中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3539-3540.doi: 10.4103/NRR.NRR-D-25-00376

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

神经源性间充质干细胞的雪旺之歌:识别脂肪和骨髓中替代的神经祖细胞

  

  • 出版日期:2026-08-18 发布日期:2026-04-25

The Schwann Song of Neurogenic MSCs: Identifying an Alternative Neural Progenitor in Adipose and Bone Marrow

Rhian Stavely*, Leah C. Ott   

  1. Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Online:2026-08-18 Published:2026-04-25
  • Contact: Rhian Stavely, PhD, rstavely@mgh.harvard.edu.

摘要: https://orcid.org/0000-0002-5099-3704 (Rhian Stavely)

Abstract: Multipotent stromal cells, otherwise known as mesenchymal stem cells (MSCs), have been widely studied for their regenerative potential across multiple tissues, including the nervous system (Caplan, 2017). Reports suggesting that MSCs can differentiate into neurons and glia spurred optimism towards their future therapeutic application in nervous system disorders. Despite extensive research, however, the precise cellular mechanisms underlying their neural differentiation potential are unclear (George et al., 2019). Nevertheless, MSCs have been utilized in hundreds of clinical trials for neural regeneration following stroke, traumatic brain injury, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease among others (Andrzejewska et al., 2021). Albeit, MSCs appear to exert therapeutic effects without explicit cell engraftment, informing the prevailing hypothesis that they act via a ‘hit and run’ mechanism to stimulate regeneration of host tissues via their secretome, exosomes, or other pathways, rather than integrating into the regenerated tissue themselves (Caplan, 2017).