中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3561-3562.doi: 10.4103/NRR.NRR-D-25-01018

• 观点:退行性病与再生 • 上一篇    下一篇

少突胶质细胞铁死亡:多发性硬化症的新机制

  

  • 出版日期:2026-08-18 发布日期:2026-04-25

Oligodendrocyte ferroptosis: Novel mechanisms in multiple sclerosis

Valentina Saverio, Dmitry Lim, Marco Corazzari*   

  1. Department of Health Sciences, School of Medicine, Center for Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale, Novara, Italy (Saverio V, Corazzari M)
    Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy (Saverio V, Lim D)
  • Online:2026-08-18 Published:2026-04-25
  • Contact: Marco Corazzari, PhD, marco.corazzari@uniupo.it.

摘要: https://orcid.org/0000-0002-6246-5968 (Marco Corazzari)

Abstract: Myelination in the central nervous system (CNS) is a highly intricate process, exclusive to vertebrates, that relies on the coordinated interaction between oligodendrocytes (OLs) and neurons. In addition to their role in forming myelin, accumulating evidence indicates that OLs provide crucial trophic support to axons, contributing to normal CNS function. Notably, OL injury and loss are observed in a variety of human conditions, including stroke, traumatic injuries of the brain and spinal cord, as well as neurodegenerative disorders such as multiple sclerosis (MS).