中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (8): 3567-3568.doi: 10.4103/NRR.NRR-D-25-01010

• 观点:退行性病与再生 • 上一篇    下一篇

多组学视角解读肌萎缩性侧索硬化症

  

  • 出版日期:2026-08-18 发布日期:2026-04-25

Seeing amyotrophic lateral sclerosis in a multi-omic perspective

Natalie Dikwella, Paul Lingor, Laura Tzeplaeff*   

  1. Department of Neurology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Munich, Germany (Dikwella N, Lingor P, Tzeplaeff L)
    German Center for Neurodegenerative Diseases (DZNE), München, Germany (Lingor P)
    Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (Lingor P)

  • Online:2026-08-18 Published:2026-04-25
  • Contact: Laura Tzeplaeff, PhD, laura.tzeplaeff@tum.de.

摘要: https://orcid.org/0009-0003-7643-3232 (Laura Tzeplaeff)

Abstract: Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, leading to muscle weakness, paralysis and ultimately death due to respiratory failure. Currently licensed drugs have only very limited effects on slowing down disease progression or biomarkers. Despite numerous successful preclinical analyses, most new drugs fail when translated to clinical trials (Petrov et al., 2017). This is believed to be, in part, due to the multilayer heterogeneity of ALS (e.g., clinical, genetic, and molecular; Tzeplaeff et al., 2024). Studies integrating multi-omic data are still limited, making it difficult to fully understand the biological complexity that characterizes the disease.