中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 4231-4232.doi: 10.4103/NRR.NRR-D-25-00454

• 观点:退行性病与再生 • 上一篇    下一篇

胎盘生长因子介导的血管生成信号在白质损伤和认知能力下降中的作用

  

  • 出版日期:2026-09-15 发布日期:2026-05-11

Role of angiogenic signaling through placental growth factor in white matter injury and cognitive decline

Madhavi Akella, Parissa Irom, Kyle C. Kern, Jason D. Hinman*   

  1. Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
  • Online:2026-09-15 Published:2026-05-11
  • Contact: Jason D. Hinman, MD, PhD, jhinman@mednet.ucla.edu.
  • Supported by:
    This work was supported by the following grants: NS100608 and NS100614.

摘要: https://orcid.org/0000-0002-0872-5044 (Jason D. Hinman)

Abstract: Vascular contributions to cognitive impairment and dementia (VCID) remain a significant public health concern. Age-associated disruptions in cerebral blood flow and brain vascular permeability resulting from cerebral small vessel disease (CSVD) are the main drivers of VCID. There is a stark absence of pharmacological treatments specific to CSVD, in part due to challenges in diagnostic accuracy for CSVD pathology during the prodromal phase before clinical dementia. Magnetic resonance imaging (MRI) is the benchmark method for detecting cerebrovascular pathologies, which predominate in subcortical white matter regions. Advanced MRI techniques, including diffusion tensor imaging (DTI), which have higher diagnostic accuracy for prodromal CSVD are not routinely acquired in clinical scans. Highly sensitive and accurate blood-based biomarkers that inform the pathogenic cascades associated with CSVD and VCID offer a minimally invasive means of identifying individuals who are at risk for VCID.