中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (9): 4265-4266.doi: 10.4103/NRR.NRR-D-25-01140

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

影响神经干/祖细胞移植治疗效果的因素

  

  • 出版日期:2026-09-15 发布日期:2026-05-14

Factors influencing efficacy of neural stem and progenitor cell transplantation

Angelina Baltazar, Jennifer N. Dulin*   

  1. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Baltazar A)
    Department of Biology, Texas A&M University, College Station, TX, USA (Dulin JN)
    Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, USA (Dulin JN)
  • Online:2026-09-15 Published:2026-05-14
  • Contact: Jennifer N. Dulin, PhD, jdulin@bio.tamu.edu.
  • Supported by:
    This work was supported by the National Institutes of Health (R01NS116404 to JND) and Mission Connect, a program of TIRR Foundation (#021-101 to JND).

摘要: https://orcid.org/0000-0001-5767-4290 (Jennifer N. Dulin)

Abstract: Neural stem and progenitor cell (NSPC) transplantation holds promise for treating neurological injuries and diseases, yet the mechanisms underlying therapeutic efficacy remain incompletely understood. This Perspective highlights emerging evidence that synaptic connectivity between transplanted cells and host circuits is a key determinant of functional recovery. Drawing on analyses in spinal cord injury, traumatic brain injury, and Parkinson’s disease (PD), we argue that factors such as donor cell identity, graft-host compatibility, and neuronal phenotype critically influence outcomes. A deeper understanding of circuit integration will be essential for optimizing NSPC-based therapies and advancing clinicaltranslation.