中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (10): 4886-4887.doi: 10.4103/NRR.NRR-D-25-01296

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

克服扩散限制推进脑类器官

  

  • 出版日期:2026-10-15 发布日期:2026-06-13

Overcoming diffusion limits to advance brain organoids

Xuyu Qian*   

  1. Division of Neurology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; 
    Center for Brain Research Initiative in Development, Genetics, and Engineering, Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA; 
    Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  • Online:2026-10-15 Published:2026-06-13
  • Contact: Xuyu Qian, PhD, qianx@chop.edu.
  • Supported by:
    This work was supported by the Pathway to Independence Award from the NINDS (4R00NS135123-02) (to XQ).

摘要: https://orcid.org/0000-0001-5944-3816 (Xuyu Qian)

Abstract: Human pluripotent stem cell–derived brain organoids have become a central tool for modeling human neurodevelopment. Compared to traditional in vitro systems, brain organoids are distinguished by their ability to allow cells to self-organize and follow intrinsic developmental programs, thereby dynamically recapitulating aspects of in vivo brain development. Cerebral cortex organoids, for instance, can robustly mimic many features of human brain formation during mid-gestation. However, current methodologies remain largely restricted to modeling processes that occur prior to the late second trimester.