中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (10): 4890-4891.doi: 10.4103/NRR.NRR-D-25-01239

• 观点:退行性病与再生 • 上一篇    下一篇

帕金森病体液和组织生物标志物的进展及未满足需求

  

  • 出版日期:2026-10-15 发布日期:2026-06-13

Advances and unmet needs in fluid and tissue biomarkers in Parkinson’s disease

Ravi Rajmohan, Claire Henchcliffe*   

  1. Department of Neurology, University of California, Irvine, CA, USA
  • Online:2026-10-15 Published:2026-06-13
  • Contact: Claire Henchcliffe, MD, DPhil, chenchcl@hs.uci.edu.
  • Supported by:
    This work was partly supported by a grant from Enroll HD (to RR).

摘要: https://orcid.org/0000-0002-0899-3030 (Claire Henchcliffe)

Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world and is increasing in prevalence. However, with multiple known risk factors and shortcomings in understanding the multifaceted aspects of this disease, there are as yet no cures and no established disease-modifying interventions. Historically, insights on pathogenesis have primarily come from autopsy studies, and one concern is that the pathological diagnosis does not always correspond to the clinical diagnosis (Hughes et al., 1992). This greatly limits our ability to investigate critical aspects of how the disease forms and progresses during life. In turn, this affects multiple aspects of care and research, including not only diagnosis, but appropriate subtyping that would be clinically meaningful, stratification for clinical trials, and providing optimal outcome measures for target engagement and treatment efficacy.