中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (10): 4894-4895.doi: 10.4103/NRR.NRR-D-25-01268

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

视网膜培养皿:Tau 蛋白病和视网膜神经变性的转化平台

  

  • 出版日期:2026-10-15 发布日期:2026-06-13

Retina-on-a-dish: A translational platform for tauopathy and retinal neurodegeneration

Chiara D’Antoni#, Lorenza Mautone#, Ylenia Gigante, Anna Mirone, Silvia Di Angelantonio*   

  1. Department of Physiology and Pharmacology “V. Erspamer” and Center for Research in Neurobiology “Daniel Bovet”, Sapienza University of Rome, Roma, Italy (D’Antoni C, Mautone L, Mirone A, Di Angelantonio S) 
    Center for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia, Roma, Italy (D’Antoni C, Mautone L, Gigante Y, Mirone A, Di Angelantonio S) 
    D-Tails Research srl BC, Rome, Italy (Gigante Y, Di Angelantonio S)
  • Online:2026-10-15 Published:2026-06-13
  • Contact: Silvia Di Angelantonio, PhD, silvia. diangelantonio@uniroma1.it.
  • Supported by:
    This work was supported by D-Tails-IIT Joint Lab; Progetto ECS 0000024 Rome Technopole, Grant/Award Number: CUP B83C22002820006; PNRR Missione 4 Componente 2 Investimento 1.5, Italian; Ministry of Health (MoH) Alternative Methods to Animal Testing Grant 2023, Grant/Award Number: NEURO-3R; Regione Lazio, Grant/Award Number: A0112E0073; Italian Ministry of University and Research (MUR), Grant/Award Numbers: FISA-2023-00045, CUPB83D23001150001, PRIN2022 CUP2022CFP7RF (all to SDA).

摘要: https://orcid.org/0000-0003-1434-3648 (Silvia Di Angelantonio)

Abstract: The intersection of retinal and neurodegenerative disease has drawn increasing attention, revealing the retina not only as a passive bystander but also as an active participant in central nervous system (CNS) pathology. Tauopathies such as Alzheimer’s disease (AD) and frontotemporal dementia are characterized by intracellular tau accumulation and synaptic dysfunction—hallmarks that have been observed in the retina of patients and animal models. Amyloid-beta (Aβ) pathology, another defining feature of AD, has similarly been detected in retinal tissues (Gupta et al., 2021; Gaire et al., 2024; Davis et al., 2025). This convergence supports a growing paradigm in which the retina serves as both a surrogate marker and a mechanistic substrate for CNS disease progression. Induced pluripotent stem cell (iPSC)-derived retinal systems, including 2D retinal neurons, 3D retinal organoids, and iPSC-derived retinal pigment epithelium, are redefining how we model neurodegeneration. These human-based platforms offer direct access to disease-relevant phenotypes, genetic precision, and the possibility of patient-specific studies. This article explores how these models illuminate taudriven pathology, enable mechanistic dissection, and hold promise for therapeutic and biomarker development in neurodegenerative and retinal diseases.