中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (17): 1352-1359.

• 综述:脊髓损伤修复保护与再生 • 上一篇    

MicroRNAs as potential therapeutics for treating spinal cord injury

  

  • 收稿日期:2012-02-22 修回日期:2012-05-03 出版日期:2012-06-15 发布日期:2012-06-15

MicroRNAs as potential therapeutics for treating spinal cord injury

Hualin Yan1, 2, Peiwei Hong1, Mei Jiang1, Hedong Li1   

  1. 1  West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    2  West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2012-02-22 Revised:2012-05-03 Online:2012-06-15 Published:2012-06-15
  • Contact: Hedong Li, Ph.D., Professor, West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China hedongli@scu.edu.cn
  • About author:Hualin Yan, West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China

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Abstract:

MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.

Key words: microRNAs, spinal cord injury, reactive astrogliosis, axonal regeneration, antagomir, anti-miR, neural regeneration, reviews