中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (16): 1241-1246.

• 原著:颅神经损伤修复保护与再生 • 上一篇    下一篇

Influence of chronic intermittent hypoxia on  growth associated protein 43 expression in the hippocampus of young rats

  

  • 收稿日期:2012-02-23 修回日期:2012-04-23 出版日期:2012-06-05 发布日期:2012-06-05

Influence of chronic intermittent hypoxia on  growth associated protein 43 expression in the hippocampus of young rats

Yan Chen1, Chunling Zhao1, Chunlai Zhang1, Lirong Luo2, Guang Yu1   

  1. 1  Department of Physiology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China
    2  Functional Experiment Center of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
  • Received:2012-02-23 Revised:2012-04-23 Online:2012-06-05 Published:2012-06-05
  • Contact: Yan Chen, Department of Physiology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China cy980430@163.com
  • About author:Yan Chen★, Master, Lecturer, Department of Physiology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China

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Abstract:

This study aimed to explore the pathological change to hippocampal neurons and the expression of growth associated protein 43 in 21-day-old young rats following chronic intermittent hypoxia. Hematoxylin-eosin staining results showed varying degrees of degeneration and necrosis in hippocampal neurons depending on the modeling time. Immunohistochemistry revealed that growth associated protein 43 expression in young rats following chronic intermittent hypoxia decreased, but that levels were still higher than those of normal rats at each time point, especially  4 weeks after modeling. During 1-5 weeks after modeling, a slow growth in rat weight was observed. Experimental findings indicate that chronic intermittent hypoxia may induce growth dysfunction and necrosis of hippocampal neurons, as well as increase the expression of growth associated protein 43 in young rats.

Key words: chronic intermittent hypoxia, brain injury, growth associated protein 43, obstructive sleep apnea hypopnea syndrome, hippocampus, young rats, neural regeneration