中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (10): 1719-1720.doi: 10.4103/1673-5374.257517

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

微调生长锥对导向因子的反应:microRNA的作用

  

  • 出版日期:2019-10-15 发布日期:2019-10-15

Fine-tuning the response of growth cones to guidance cues: a perspective on the role of microRNAs

Sarah E. Walker, Gaynor E. Spencer, Robert L. Carlone   

  1. Department of Biological Sciences, Brock University, Ontario, Canada
  • Online:2019-10-15 Published:2019-10-15
  • Contact: Robert L. Carlone, PhD, rcarlone@brocku.ca.
  • Supported by:

    This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada (2015-03780, to GES; and 2017-00008, to RLC)

摘要:

orcid: 0000-0002-5007-2921 (Robert L. Carlone)

Abstract:

In the development and regeneration of the nervous system, neurons face the complex task of establishing and/or repairing neuronal connections and contacts. The formation of these neuronal circuits is largely coordinated by tightly regulated temporal and spatial changes in mRNA translation, which enables incredibly precise control over protein expression and localization. Local mRNA translation in specific cellular compartments appears to play a role in many processes that are important to nervous system development and regeneration, including: cell survival, migration, growth cone guidance, and synaptogenesis.