中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (15): 1132-1137.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Wendan decoction improves learning and memory deficits in a rat model of schizophrenia

  

  • 收稿日期:2011-12-01 修回日期:2012-03-24 出版日期:2012-05-25 发布日期:2012-05-25

Wendan decoction improves learning and memory deficits in a rat model of schizophrenia

Cuiping Yang1, Changchun Cai2, Xiaojin Yang3, Yanping Yang4, Zhigang Zhou1, Jianhua Liu1, Heping Ye1, Hongjiao Wan1   

  1. 1 Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China   
    2 Affiliated Hospital of Jiujiang University of Jiangxi Province, Jiujiang 332000, Jiangxi Province, China   
    3 Grade 2010 Postgraduate, Medical School of Nanchang University, Nanchang 330006, Jiangxi Province, China   
    4 Grade 2010 Postgraduate, Xuzhou Medical College, Xuzhou 221004, Jiangsu Province, China
  • Received:2011-12-01 Revised:2012-03-24 Online:2012-05-25 Published:2012-05-25
  • Contact: Hongjiao Wan, M.D., Professor, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China Ann.wan@163.com
  • About author:Cuiping Yang☆, Studying for doctorate, Lecturer, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China

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Abstract:

An experimental model of schizophrenia was established using dizocilpine (MK-801). Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment.

Key words: Wendan decoction, schizophrenia, Morris water maze, long-term potentiation, hippocampus, learning and memory, traditional Chinese medicine, neural regeneration