中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (15): 1145-1150.

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity

  

  • 收稿日期:2011-11-01 修回日期:2012-02-24 出版日期:2012-05-25 发布日期:2012-05-25

Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity

Chen Zhao1, Li Qi2, Luyi Wu3, Tao Yi2, Huangan Wu1, Xinxin Guo2, Cili Zhou2, Huirong Liu1, Xiaomei Wang2   

  • Received:2011-11-01 Revised:2012-02-24 Online:2012-05-25 Published:2012-05-25
  • Contact: Xiaomei Wang, Associate professor, M.D., Master’s supervisor, Key Unit of Acupuncture-Moxibustion and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China; Huangan Wu, Professor, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China wxm123@vip.sina.com; wuhuangan@126.com
  • About author:Chen Zhao☆, M.D., Associate chief physician, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

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Abstract:

Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia.

Key words: suspended moxibustion, chronic visceral hypersensitivity, irritable bowel syndrome, prokineticin 1, prokineticin receptor 1, spinal cord, neural regeneration