中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (15): 1185-1191.

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway

  

  • 收稿日期:2011-11-10 修回日期:2012-03-20 出版日期:2012-05-25 发布日期:2012-05-25

Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway

Zhongqiu Wen, Wenqin Zeng, Jingxing Dai, Xin Zhou, Chun Yang, Fuhua Duan, Yufeng Liu, Huiying Yang, Lin Yuan   

  1. Key Laboratory of Tissue Construction and Detection of Guangdong Province, Department of Anatomy, Southern Medical University, Guangzhou 510515, Guangdong Province, China
  • Received:2011-11-10 Revised:2012-03-20 Online:2012-05-25 Published:2012-05-25
  • Contact: Lin Yuan, Ph.D., Professor, Doctoral supervisor, Key Laboratory of Tissue Construction and Detection of Guangdong Province, Department of Anatomy, Southern Medical University, Guangzhou 510515, Guangdong Province, China; Jingxing Dai, Ph.D., Associate professor, Key Laboratory of Tissue Construction and Detection of Guangdong Province, Department of Anatomy, Southern Medical University, Guangzhou 510515, Guangdong Province, China yuanlfascia@yahoo.com.cn daijingxing@yahoo.com.cn
  • About author:Zhongqiu Wen☆, Studying for doctorate, Attending physician, Key Laboratory of Tissue Construction and Detection of Guangdong Province, Department of Anatomy, Southern Medical University, Guangzhou 510515, Guangdong Province, China

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Abstract:

Massage in traditional Chinese medicine can promote body and brain development of premature and normal newborn infants. In the present study, neonatal rats (1 day old) underwent paravertebral fascial massage (15 consecutive days), followed by subcutaneous injection of insulin-like growth factor 1 receptor antagonist, JB1 (9 consecutive days). Paravertebral fascial massage significantly increased insulin-like growth factor 1 expression and cell proliferation in the subventricular zone of the lateral ventricle and dentate gyrus of the hippocampus. However, JB1 inhibited this increase. Results suggest that paravertebral fascial massage can promote brain development of neonatal rats via the insulin-like growth factor 1 pathway.

Key words: paravertebral fascial massage, insulin-like growth factor 1, neurogenesis, immunohistochemistry, neural regeneration