中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (2): 257-258.doi: 10.4103/1673-5374.265550

• 观点:退行性病与再生 • 上一篇    下一篇

阿尔茨海默病病理和视网膜神经退行性疾病的补体途径:未来之路

  

  • 出版日期:2020-02-15 发布日期:2020-05-25

Complement pathway in Alzheimer’s pathology and retinal neurodegenerative disorders – the road ahead.

Mehdi Mirzaei1,2,3, Liting Deng1, Veer Bala Gupta4, Stuart Graham3, Vivek Gupta3   

  1. 1Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia  2Australian Proteome Analysis Facility, Macquarie University, Sydney, NSW, Australia  3Department of Clinical Medicine, Macquarie University, Sydney, NSW, Australia 4School of Medicine, Deakin University, Geelong, VIC, Australia
  • Online:2020-02-15 Published:2020-05-25
  • Contact: Mehdi Mirzaei, PhD, mehdi.mirzaei@mq.edu.au; Vivek Gupta, PhD, vivek.gupta@mq.edu.au.
  • Supported by:
    This work was supported by Ophthalmic Research Institute of Australia (ORIA), NHMRC, Macquarie University, and the Australian Government’s National Collaborative Research Infrastructure Scheme (NCRIS).

摘要: orcid: 0000-0001-8727-4984 (Mehdi Mirzaei)

Abstract: Chronic inflammation has increasingly been acknowledged as a hallmark feature of several progressive neurodegenerative disorders. Accruing evidence indicates that sustained inflammation compromises the core neuroprotective mechanisms underlying neural injury in Alzheimer’s disease (AD) and retinal neurodegenerative disorders. Innate immunity and activation of the classical complement pathways are suggested to play important roles in normal central nervous system physiology and complex tissue remodeling during the disease process (Gasque et al., 2000). The pathway is implicated in normal brain development and is also involved in the inflammatory response in a wide range of neurodegenerative conditions either directly or indirectly through recruitment and activation of immune cells. The classical, alternative and lectin complement pathways, together encompass about 30 plasma and membrane-bound proteins. The classical pathway is comprised of about 20 proteins including several serine proteinases and proteinase inhibitors connected as part of an amplifying cascade. Activation of the classical pathway is triggered once C1q is attached to the immune complexes containing IgG or IgM leading to production of the C3 convertase