中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (14): 1113-1118.

• 原著:退行性病与再生 • 上一篇    

Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression

  

  • 收稿日期:2012-02-24 修回日期:2012-04-23 出版日期:2012-05-15 发布日期:2012-05-15

Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression

Guiqing Zhang, Yanxia Zhang, Jianxia Yang, Min Hu, Yueqi Zhang, Xia Liang   

  1. Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China
  • Received:2012-02-24 Revised:2012-04-23 Online:2012-05-15 Published:2012-05-15
  • Contact: Xia Liang, Studying for master’s degree, Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China Firstli@126.com
  • About author:Guiqing Zhang, Chief physician, Professor, Master’s supervisor, Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China

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Abstract:

The study examined plasma metabolite changes of monoamine neurotransmitters in patients with treatment-resistant depression (TRD) and non-TRD before and after therapy. All 30 TRD and 30 non-TRD patients met the diagnostic criteria for a depressive episode in accordance with the International Classification of Diseases, Tenth Revision. Before treatment, and at 4, 6, and 8 weeks after treatment, the plasma metabolite products of monoamine neurotransmitters in TRD group, including 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl ethylene glycol and homovanillic acid, were significantly lower than those in the non-TRD group. After two types of anti-depressive therapy with 5-serotonin and norepinephrine reuptake inhibitor, combined with psychotherapy, the Hamilton Depression Rating Scale scores were significantly reduced in both groups of patients, and the serous levels of 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenyl ethylene glycol were significantly increased. In contrast, the homovanillic acid level exhibited no significant change. The levels of plasma metabolite products of peripheral monoamine neurotransmitters in depressive patients may predict the degree of depression and the therapeutic effects of treatment.

Key words: treatment-resistant depression, monoamine neurotransmitter, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl ethylene glycol, homovanillic acid