中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (11): 1986-1994.

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

重复经颅磁刺激与增强运动锻炼可重塑大脑皮质可塑性

  

  • 出版日期:2020-11-15 发布日期:2020-08-04

Combined effect of repetitive transcranial magnetic stimulation and physical exercise on cortical plasticity

Ya-Wen Yang1, Wen-Xiu Pan1, Qing Xie1, 2   

  1. 1 Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    2 Department of Rehabilitation Medicine, Shanghai Ruijin Rehabilitation Hospital, Shanghai, China
  • Online:2020-11-15 Published:2020-08-04
  • Contact: Qing Xie, MS, ruijin_xq@163.com.
  • Supported by:
    This work was supported by the Shanghai Jiao Tong University School of Medicine-Institute of Neuroscience, Chinese Academy of
    Sciences, Leading Startup Project of Brain Diseases Clinical Research Center of China, No. 2017NKX002 (to QX).

摘要: orcid: 0000-0002-3298-1072 (Qing Xie)

Abstract: Physical exercise can minimize dysfunction and optimize functional motor recovery after stroke by modulating cortical plasticity. However, the limitation of physical exercise is that large amounts of time and effort are necessary to significantly improve motor function, and even then, substantial exercise may not be sufficient to normalize the observed improvements. Thus, interventions that could be used to strengthen physical exercise-induced neuroplasticity may be valuable in treating hemiplegia after stroke. Repetitive transcranial magnetic stimulation seems to be a viable strategy for enhancing such plasticity. As a non-invasive cortical stimulation technique, repetitive transcranial magnetic stimulation is able to induce longterm plastic changes in the motor system. Recently, repetitive transcranial magnetic stimulation was found to optimize the plastic changes caused by motor training, thereby enhancing the long-term effects of physical exercise in stroke patients. Therefore, it is believed that the combination of repetitive transcranial magnetic stimulation and physical exercise may represent a superior method for restoring motor function after stroke.

Key words: functional recovery, motor cortex, neuroplasticity, physical exercise, primary motor cortex, repetitive transcranial magnetic stimulation, stroke