中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (12): 2253-2254.doi: 10.4103/1673-5374.284990

• 观点:退行性病与再生 • 上一篇    下一篇

长链非编码RNA在阿尔茨海默病中作用的最新进展

  

  • 出版日期:2020-12-15 发布日期:2020-08-04

Recent advances on the role of long non-coding RNAs in Alzheimer’s disease

Kyle Doxtater1, Manish K. Tripathi2, Mohammad Moshahid Khan3   

  1. 1 Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA  2 Department of immunology and Microbiology, University of Texas Rio Grande Valley, McAllen, TX, USA  3 Department of Neurology, College of Medicine; Division of Rehabilitation Sciences and Department of Physical Terapy, College of Health Professions, University of Tennessee Health Science Center, Memphis, TN, USA 
  • Online:2020-12-15 Published:2020-08-04
  • Contact: Mohammad Moshahid Khan, PhD, mkhan26@uthsc.edu; Manish K. Tripathi, PhD, manish.tripathi@utrgv.edu.
  • Supported by:
    Our work on lncRNA in AD was supported by the Division of Rehabilitation Sciences, College of Health Professions, University of Tennessee Health Science Center.

摘要: orcid: 0000-0003-4679-294X (Mohammad Moshahid Khan) 

Abstract: Dementia is a progressive cognitive impairment that affects the activities of daily living. Alzheimer’s disease (AD) is the most common form of the dementia worldwide accounting for 60–80% of all dementia cases. With an estimated cost exceeding $290 billion in the USA, understanding and devel- opment of future therapeutic strategies is vital. In this perspective, we will be examining the current thinking of AD research and therapeutic strate- gies, while proposing a possible new direction for diagnosis, understanding, and treatment targets. Non-coding RNA accounts for the largest popu- lation of the human transcriptome. Long noncoding RNA (lncRNA) is a recent molecule of interest in the biomedical research which is non protein coding and is of length greater than 200 nucleotides. LncRNAs have been shown to play diverse roles within the cells such as posttranscriptional and posttranslational regulation, chromatin modulation, and protein complex organization. Given the fexible and diverse role in disease pathophysiology, lncRNAs may serve as novel therapeutic targets for diagnosis and treatment. Evidently, recent studies showed that dysregulation of lncRNA infuences the clinical course of tumorigenesis, neurological disorders, cardiovascular disease, diabetes, and acquired immunodefciency syndrome (Kazimierczyk et al., 2020). Tis indicates that lncRNA can provide a unique avenue of re- search and possible therapeutic targets in AD.