中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (11): 2029-2030.doi: 10.4103/1673-5374.282241

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

运动、小胶质细胞及其他 --- 与小胶质细胞沟通的锻炼

  

  • 出版日期:2020-11-15 发布日期:2020-08-06

Exercise, microglia, and beyond – workout to communicate with microglia

Megumi Andoh, Ryuta Koyama   

  1. Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Online:2020-11-15 Published:2020-08-06
  • Contact: Ryuta Koyama, PhD,rkoyama@mol.f.u-tokyo.ac.jp.
  • Supported by:
    This work was supported in part by a Grant-in-Aid for Scientific Research (B) (17H03988, to RK) from JSPS and JST PRESTO (JPMJPR18H4, to RK).

摘要: orcid: 0000-0001-7108-174X (Ryuta Koyama)

Abstract: Microglia are brain-resident immune cells that use their ramified processes to survey the brain parenchyma. They maintain brain ho- meostasis by mediating immune responses through cytokine release, phagocytosing pathogens and protein aggregation (Salter et al., 2017). Furthermore, in both healthy and disease states, microglia interacting with neurons regulate synaptic formation, elimination and plasticity (Salter et al., 2017). It is thought that these functions may be altered by environmental stimuli such as lifestyle, stress, infection and air pollu- tion, the effects of which may result in brain dysfunction and the de- velopment of neurodegenerative diseases (Branchi et al., 2014; Hanam- sagar et al., 2017).