中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (11): 2037-2038.doi: 10.4103/1673-5374.282250

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

Nogo-A与神经递质受体的调节

  

  • 出版日期:2020-11-15 发布日期:2020-08-06

Nogo-A and the regulation of neurotransmitter receptors

Bor Luen Tang   

  1. Department of Biochemistry, Yong Loo Lin School of Medicine; National University of Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
  • Online:2020-11-15 Published:2020-08-06
  • Contact: Bor Luen Tang, PhD, bchtbl@nus.edu.sg.
  • Supported by:
    BLT was supported by the NUS Graduate School for Integrative Sciences and Engineering.

摘要: orcid: 0000-0002-1925-636X (Bor Luen Tang)

Abstract: Nogo-A is known to restrict plasticity in the adult central nervous system, and signalling through its cognate receptors modulates synaptic spine architecture and excitatory glutamate transmission via restricting synaptic glutamate receptor levels and their delivery to the post-synaptic compartments. A recent report now indicates that Nogo-A, signaling through Sphingosine-1-Phosphate Receptor 2, also strengthens inhibitory gamma amino acid butyric acid (GABA)ergic transmission by limiting the diffusion dynamics of GABAA receptors. This reciprocal modulation of excitatory and inhibitory signaling via neurotransmitter receptor dynamics by Nogo-A likely plays important pathophysiological roles in synaptic plasticity during development and injury.