中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (12): 900-905.

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction

  

  • 收稿日期:2011-10-15 修回日期:2012-02-20 出版日期:2012-04-25 发布日期:2012-04-25

Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction

Ruiman Xie1, Min Fang1, Linjiang Zhou2, Shanghua Fan1, Jianying Liu1, Hongbo Quan1, Man Luo1, Dongying Qiu1   

  1. 1  Department of Neurology and Gerontology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    2  Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2011-10-15 Revised:2012-02-20 Online:2012-04-25 Published:2012-04-25
  • Contact: Linjiang Zhou, M.D., Ph.D., Professor, Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China; Min Fang, Master, Department of Neurology and Gerontology, Zhongshan Hospital, Fudan University, Shanghai 200032, China zhoulinjiang@yahoo.com.cn;fangmin-dr@sohu.com
  • About author:Ruiman Xie☆, M.D., Ph.D., Professor, Department of Neurology and Gerontology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

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Abstract:

To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction. The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days. The diffusion coefficient remained unchanged. Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction.

Key words: corticospinal tracts, Wallerian degeneration, fractional anisotropy, diffusion tensor imaging, neuroimaging, neural regeneration