中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (9): 1623-1630.doi: 10.4103/1673-5374.276321

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

对白金诱发的周围神经病变的认识–当前观点

  

  • 出版日期:2020-09-08 发布日期:2020-09-24

Insights into platinum-induced peripheral neuropathy–current perspective

Andrijana Lazić1 , Jelena Popović2 , Tatjana Paunesku2 , Gayle E. Woloschak2 , Milena Stevanović1, 3, 4, *   

  1. 1 Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia 2 Feinberg School of Medicine, Department of Radiation Oncology, Northwestern University, Chicago, IL, USA 3 Faculty of Biology, University of Belgrade, Belgrade, Serbia 4 Serbian Academy of Sciences and Arts, Belgrade, Serbia
  • Online:2020-09-08 Published:2020-09-24
  • Contact: Milena Stevanović, PhD, milenastevanovic@imgge.bg.ac.rs.
  • Supported by:
    This work was supported by grant from the Ministry of Education, Science and Technological Development, Republic of Serbia (173051). JP was also supported by a UICC Yamagiwa-Yoshida Memorial International Cancer Study Grant (YY2/2015/381414).

摘要: orcid:  0000-0003-4286-7334 (Milena Stevanović)

Abstract: Cancer is a global health problem that is often successfully addressed by therapy, with cancer survivors increasing in numbers and living longer world around. Although new cancer treatment options are continuously explored, platinum based chemotherapy agents remain in use due to their efficiency and availability. Unfortunately, all cancer therapies affect normal tissues as well as cancer, and more than 40 specific side effects of platinum based drugs documented so far decrease the quality of life of cancer survivors. Chemotherapy-induced peripheral neuropathy is a frequent side effects of platinum-based chemotherapy agents. This cluster of complications is often so debilitating that patients occasionally have to discontinue the therapy. Sensory neurons of dorsal root ganglia are at the core of chemotherapy-induced peripheral neuropathy symptoms. In these postmitotic cells, DNA damage caused by platinum chemotherapy interferes with normal functioning. Accumulation of DNA-platinum adducts correlates with neurotoxic severity and development of sensation of pain. While biochemistry of DNA-platinum adducts is the same in all cell types, molecular mechanisms affected by DNA-platinum adducts are different in cancer cells and non-dividing cells. This review aims to raise awareness about platinum associated chemotherapy-induced peripheral neuropathy as a medical problem that has remained unexplained for decades. We emphasize the complexity of this condition both from clinical and mechanistical point of view and focus on recent findings about chemotherapy-induced peripheral neuropathy in in vitro and in vivo model systems. Finally, we summarize current perspectives about clinical approaches for chemotherapy-induced peripheral neuropathy treatment.

Key words: chemotherapy-induced peripheral neuropathy, CIPN, DNA-Pt adducts, dorsal root ganglia, DRG, model systems, molecular mechanisms, neurotoxic, platinum based chemotherapy, Pt, sensory neurons treatment, side effects