中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (12): 924-931.

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis

  

  • 收稿日期:2011-12-06 修回日期:2012-03-20 出版日期:2012-04-25 发布日期:2012-04-25

Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis

Yanbo Liu, Chunming Miao, Zhenjiang Wang, Xin He, Weigao Shen   

  1. Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China
  • Received:2011-12-06 Revised:2012-03-20 Online:2012-04-25 Published:2012-04-25
  • Contact: Weigao Shen, Ph.D., Associate professor, Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China shenweigao@163.com
  • About author:Yanbo Liu☆, Ph.D., Professor, Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China Yanbo Liu and Chunming Miao contributed equally to this work.

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Abstract:

A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma.

Key words: RNA interference, survivin, glioblastoma, apoptosis