中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (1): 101-103.doi: 10.4103/1673-5374.286959

• 观点:退行性病与再生 • 上一篇    下一篇

白藜芦醇作为自噬的诱导剂:是否有独特的活化途径?

  


  • 出版日期:2021-01-15 发布日期:2020-11-25

Resveratrol as an inductor of autophagy: is there a unique pathway of activation?

Narayana Pineda-Ramírez, Penélope Aguilera*   

  1. Laboratorio de Patología Vascular Cerebral. Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México
  • Online:2021-01-15 Published:2020-11-25
  • Contact: Penélope Aguilera, PhD, penelope.aguilera@gmail.com.
  • Supported by:
    This work was supported by the CONACYT (CB-21012-01-182266). Anayeli Narayana Pineda-Ramírez is a doctoral student from Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM) and receiver scholarship (Number 484304) from CONACYT. 

摘要: https://orcid.org/0000-0003-2288-1251(Penélope Aguilera) 

Abstract: Autophagy is a process of cellular degradation for the removal of damaged components and eventual recycling of the resulting molecules that help to the maintenance of cellular homeostasis. Through this pathway, proteins with relatively long half-life and whole organelles (e.g., mitochondria, peroxisomes, and ribosomes) are degraded in the cytoplasm for the continuous turnover of cellular structures to facilitate their renewal. However, the beneficial effect of autophagy goes beyond cellular “cleaning” and resides to a large extent on its ability to recycle cell components back into the cytosol. Thus, autophagy is a fundamental mechanism to regulate cellular functions, including DNA repair, proliferation, differentiation, embryonic development, and the immune response.