中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (1): 108-109.doi: 10.4103/1673-5374.286962

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

氧化应激诱导的视神经头星形胶质细胞中的cAMP/PKA途径和线粒体保护

  

  • 出版日期:2021-01-15 发布日期:2020-11-25

cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes

Keun-Young Kim, Won-Kyu Ju*   

  1. National Center for Microscopy and Imaging Research and Department of Neurosciences, University of California San Diego, La Jolla, CA, USA (Kim KY)
    Hamilton Glaucoma Center and Shiley Eye Institute, The Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA (Ju WK)
  • Online:2021-01-15 Published:2020-11-25
  • Contact: Won-Kyu Ju, PhD, wju@ucsd.edu.

摘要: https://orcid.org/0000-0003-1117-4834 (Won-Kyu Ju) 

Abstract: Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and older. Despite the widely appreciated disease relevance of structural and functional abnormalities of astrocyte in the optic nerve head (ONH) that is associated with retinal ganglion cell (RGC) axon degeneration, the molecular mechanisms underlying astrocyte dysfunction in glaucomatous ONH degeneration are poorly understood. Oxidative stress is strongly linked to glaucoma pathogenesis, and astrocytes are the responsible cell type that is mostly related to oxidative stress and glaucomatous ONH degeneration.