中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (2): 281-282.doi: 10.4103/1673-5374.290885

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

施旺细胞中膜孕酮受体代表着促进神经再生的有希望靶标

  

  • 出版日期:2021-02-15 发布日期:2020-12-02

Membrane progesterone receptors (mPRs/PAQRs) in Schwann cells represent a promising target for the promotion of neuroregeneration 

Luca F. Castelnovo*, Peter Thomas, Valerio Magnaghi   

  1. Marine Science Institute, University of Texas at Austin, Port Aransas, TX, USA (Castelnovo LF, Thomas P)
    Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy (Magnaghi V)
  • Online:2021-02-15 Published:2020-12-02
  • Contact: Luca F. Castelnovo, PhD, luca.castelnovo@utexas.edu.

摘要: https://orcid.org/0000-0003-4784-1221(Luca F. Castelnovo)

Abstract: Peripheral nerve injury is a common cause of morbidity, which affects millions of people worldwide. The peripheral nervous system, differently from the central nervous system, has an intrinsic ability to regenerate after injury. However, in most cases the regenerative outcome is not completely satisfactory, in particular for long-gap peripheral nerve injuries in which the microsurgical approach is not possible. In these cases, the current research effort is mostly aimed at the identification of pharmacological and/or cell therapy approaches that, coupled with the use of biomaterial conduits, provide scaffold, mechanical support and guidance to the regeneration process, and can increase regeneration speed and efficiency (Faroni et al., 2015).