中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (3): 510-511.doi: 10.4103/1673-5374.293147

• 观点:退行性病与再生 • 上一篇    下一篇

胶质细胞衍生的转化生长因子β1:多发性硬化症神经炎症的关键因素

  

  • 出版日期:2021-03-15 发布日期:2020-12-17

Glial-derived transforming growth factor β1 (TGF-β1): a key factor in multiple sclerosis neuroinflammation

Coram Guevara, Fernando C. Ortiz*   

  1. Mechanisms of Myelin Formation and Repair Laboratory, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile
  • Online:2021-03-15 Published:2020-12-17
  • Contact: Fernando C. Ortiz, PhD, fernando.ortiz@uautonoma.cl.
  • Supported by:

    CG was supported by the VRIP-UA PhD fellowship. We thank Fernando Salinas Arce for his helpful corrections and comments on the manuscript.

    This work was supported by Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 11160616 and DIUA166-2019 (VRIP-UA) to FCO.

摘要: https://orcid.org/0000-0001-6341-8111 (Coram Guevara);
https://orcid.org/0000-0002-4776-4492 (Fernando C. Ortiz)

Abstract: MS is an irreversible and progressive central nervous system (CNS) disease which originates in the autoimmune attack of lymphocytes against CNS myelin. This specialized membrane, synthesized by oligodendrocytes (OL) in the CNS, provides metabolic support to axons and allows for saltatory conduction in neurons. The lack of myelin (i.e., demyelination) leads to axonal degeneration, neuronal death, and the consequent neurological disabilities (Franklin and Ffrench-Constant, 2017). Although the causes of MS are still matter of active investigation, the early events preceding the demyelination onset have been characterized in deep. Evidence indicates that there is an increase in the blood-brain barrier (BBB) permeability, followed by the infiltration of CD4+ T lymphocytes, which, in turn, induces the overactivation of microglia and astrocytes present in the white matter. The latter leads to the dysregulation of the inflammatory response, being characterized by an increased concentration of proinflammatory cytokines promoting myelin loss (recently reviewed in Varas and Ortiz, 2019).