中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (10): 772-777.

• 原著:颅神经损伤修复保护与再生 • 上一篇    下一篇

Calcium-mediated paired pulse depression in juvenile rat dorsal striatum

  

  • 收稿日期:2011-11-18 修回日期:2012-02-24 出版日期:2012-04-05 发布日期:2012-04-05

Calcium-mediated paired pulse depression in juvenile rat dorsal striatum

Yufeng Xie1, Michael F. Jackson1, 2, John F. MacDonald1, 2, 3   

  1. 1  Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    2  Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    3  Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
  • Received:2011-11-18 Revised:2012-02-24 Online:2012-04-05 Published:2012-04-05
  • Contact: John F. MacDonald, Ph.D., Professor, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada; Machael F. Jackson, Ph.D., Adjunct assistant professor, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario canadajfmacdonald@ robarts.ca; mjackson@robarts.ca
  • About author:Yufeng Xie☆, Ph.D., Research associate, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada

PDF

838

Abstract:

As the major division of the basal ganglia, neostriatum forms mutual connections with multiple brain areas and is critically involved in motor control and learning/memory. Long-term synaptic plasticity has been widely studied in different species recently. However, there are rare reports about the short-term synaptic plasticity in neostratium. In the present study, using field excitatory postsynaptic potentials recording, we reported one form of short-term synaptic plasticity that is paired pulse depression in juvenile rat dorsal striatum slices induced by stimuli of the white matter. The field excitatory postsynaptic potentials could be abolished by α-amino-3-hydroxy-5-methylizoxazole-4- propionic acid receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione, but not by gamma-aminobutyric acid type A receptor antagonist bicuculline or dopamine D1 receptor antagonist SKF-81297. The paired pulse depression in the corticostratial pathway was different from paired pulse facilitation in the hippocampal CA1 synapse. In addition, the paired pulse depression was not affected by bath application of gamma-aminobutyric acid type A receptor antagonist or dopamine D1 receptor antagonist. However, low calcium and high magnesium could attenuate the paired pulse depression. These findings suggest a more complicated plasticity form in the dorsal striatum of juvenile rats that is different from that in the hippocampus, which is related with extracellular calcium.

Key words: paired pulses depression, dorsal striatum, calcium, juvenile rats