中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (6): 1150-1157.doi: 10.4103/1673-5374.300331

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

突触可塑性和相关神经疾病中蛋白激酶和磷酸酶的功能库:综述

  

  • 出版日期:2021-06-15 发布日期:2020-12-31

Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological disorders

Raheel Khan1, 2, Don Kulasiri1, 2, *, Sandhya Samarasinghe1   

  1. 1 Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand;  2 Department of Molecular Biosciences, Lincoln University, Christchurch, New Zealand
  • Online:2021-06-15 Published:2020-12-31
  • Contact: Don Kulasiri, PhD, Don.Kulasiri@lincoln.ac.nz.

摘要: https://orcid.org/0000-0001-8744-1578 (Don Kulasiri) 

Abstract: Protein phosphorylation and dephosphorylation are two essential and vital cellular mechanisms that regulate many receptors and enzymes through kinases and phosphatases. Ca2+- dependent kinases and phosphatases are responsible for controlling neuronal processing; balance is achieved through opposition. During molecular mechanisms of learning and memory, kinases generally modulate positively while phosphatases modulate negatively. This review outlines some of the critical physiological and structural aspects of kinases and phosphatases involved in maintaining postsynaptic structural plasticity. It also explores the link between neuronal disorders and the deregulation of phosphatases and kinases.

Key words: Alzheimer’s disease, autism spectrum disorder, CaMKII, calcineurin, long-term depression, long-term potentiation, protein kinase A, protein phosphatase 1, protein dephosphorylation, protein phosphorylation