中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (6): 1200-1201.doi: 10.4103/1673-5374.300437

• 观点:退行性病与再生 • 上一篇    下一篇

病毒在帕金森病发病机制中的作用

  

  • 出版日期:2021-06-15 发布日期:2020-12-31

The role of viruses in the pathogenesis of Parkinson’s disease

José Fidel Baizabal-Carvallo*, Marlene Alonso-Juarez   

  1. Department of Science and Engineering, University of Guanajuato, México (Baizabal-Carvallo JF)
    National Polytechnic Institute, México (Alonso-Juarez M)
  • Online:2021-06-15 Published:2020-12-31
  • Contact: José Fidel Baizabal-Carvallo, MD, baizabaljf@hotmail.com.

摘要: https://orcid.org/0000-0002-8614-5563 (José Fidel Baizabal-Carvallo) 

Abstract: Parkinson’s disease (PD) is a neurological degenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (SN) and intracellular inclusions called Lewy bodies and Lewy tangles, composed mainly by aggregates of α-synuclein. Braak et al. (2003) proposed that the olfactory epithelium and intestines are the anatomical sites where PD initiates; as pathological aggregates of α-synuclein are detected in these tissues in very early or prodromal PD. In this scenario, α-synuclein seems to reach the central nervous system (CNS) by axonal transport through the sympathetic nervous system, the glossopharyngeal and vagus nerves as well as the olfactory pathways (Braak et al., 2003).