中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (7): 1415-1416.doi: 10.4103/1673-5374.300991

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

不透明带中的A13多巴胺细胞群是疼痛感受过程中的关键神经元核

  

  • 出版日期:2021-07-15 发布日期:2021-01-07

A13 dopamine cell group in the zona incerta is a key neuronal nucleus in nociceptive processing

Shunpei Moriya*, Tomoyuki Kuwaki   

  1. Department of Physiology, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan

  • Online:2021-07-15 Published:2021-01-07
  • Contact: Shunpei Moriya, MD, PhD, msmr9040psyg80@gmail.com.
  • Supported by:
    This work was supported by JSPS KAKENHI grants (19K17093 to SM, 16H05139 to TK). 

摘要: https://orcid.org/0000-0002-2242-8214 (Shunpei Moriya) 

Abstract: In stressful modern society, pain caused by physical and mental disorders is an increasing social health problem all over the world. Physical and mental activity depends on the state of various neurotransmitters in the central nervous system (CNS). Monoaminergic systems play important roles in regulating physiological functions including nociception. It is well known that in the CNS, there are descending pathways related to nociceptive processing known as the descending antinociceptive system (DAS). Noradrenalin and serotonin are major components of the DAS that form the locus coeruleus (LC)-spinal dorsal horn noradrenergic circuit and periaqueductal gray (PAG)-rostro ventricular medulla (RVM)-spinal dorsal horn serotonergic circuit (Jordan et al., 2008). Dopaminergic pathways also play roles in regulating nociceptive processing in the CNS.