中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (6): 445-450.

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury

  

  • 收稿日期:2011-09-24 修回日期:2011-12-22 出版日期:2012-02-25 发布日期:2012-02-25

7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury

Jianshi Du1, Qing Zhao2, Yingli Zhang2, Yu Wang2, Ming Ma2   

  1. 1  Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China
    2  Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China
  • Received:2011-09-24 Revised:2011-12-22 Online:2012-02-25 Published:2012-02-25
  • Contact: Qing Zhao, Doctor, Associate professor, Master’s supervisor, Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China zhaoqingjlu@163.com
  • About author:Jianshi Du☆, Doctor, Professor, Master’s supervisor, Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China

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Abstract:

In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 segments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fibroplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury.

Key words: 7, 8-dihydroxycoumarin, growth associated protein 43, sciatic nerve, peripheral nerve injury, neural regeneration