中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (6): 1228-1239.doi: 10.4103/1673-5374.327323

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

SARS-CoV-2参与中枢神经系统组织损伤

  


  • 出版日期:2022-06-15 发布日期:2021-12-16

SARS-CoV-2 involvement in central nervous system tissue damage

Muhammad Ali Haidar1, Zaynab Shakkour1, Mohammad Amine Reslan1, Nadine Al-Haj2, Perla Chamoun3, Karl Habashy1, Hasan Kaafarani4, Shima Shahjouei5, Sarah H. Farran6, Abdullah Shaito7, Esber S. Saba8, Bassam Badran9, Mirna Sabra10, *, Firas Kobeissy1, 11, *, Maya Bizri12, *   

  • Online:2022-06-15 Published:2021-12-16
  • Contact: Maya Bizri, MD, mb112@aub.edu.lb; Firas Kobeissy, MD, firasko@gmail.com; Mirna Sabra, MD, myrnasabra@hotmail.com.
  • Supported by:
    This work was partially funded by a joint grant funded by the Flash Grant Call from the National Council for Scientific Research in Lebanon (CNRS-L) and the American University of Beirut (AUB) titled: “Neurological Complications PostCoronavirus Disease (COVID-19)“ (to FK) and “SARS-COV2 antibodies signature in exposed individuals to assess protection status” (to ES).

摘要: Neural Regen Res:SARS-CoV-2入侵中枢神经系统的直接和间接途径
严重的急性呼吸综合症冠状病毒2(SARS-Cov-2)在全球持续传播,这种病毒能够攻击包括大脑在内的多个器官。临床研究表明COVID-19患者会经历一系列神经系统症状,包括从头痛到威胁生命的中风等等。尽管还没有完全了解SARS-CoV-2病毒直接影响大脑的确切机制,但研究人员提出了几种理论,包括该病毒诱导的直接和间接途径。一种可能的理论是SARS-CoV-2通过血流或通过神经末梢发生侵入大脑,并被认为是直接途径。间接机制包括血液凝固异常和免疫系统的长期激活,可能导致疾病过程中进一步的组织和器官损伤。
来自美国佛罗里达大学的Firas H Kobeissy团队在全面了解SARS-CoV-2冠状病毒神经系统感染基础上,重点阐述导致COVID-19患者出现神经系统症状的可能机制。这两种机制之间的复杂相互作用体现了SARS-CoV-2参与神经系统并发症的特点。Kobeissy团队认为进一步了解这些不同的神经系统表现,可以为遏制COVID-19传播提供预防措施,并为COVID-19的治疗提供新的治疗途径。
文章在《中国神经再生研究(英文版)》杂志2022年 6 月 6 期发表。
https://orcid.org/0000-0002-5008-6944 (Firas Kobeissy)

Abstract: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood, several theories have been suggested including direct and indirect pathways induced by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route. Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells. Nevertheless, the indirect mechanisms, including blood-clotting abnormalities and prolonged activation of the immune system, 
can result in further tissue and organ damages seen during the course of the disease. This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients. 

Key words: autoantibodies, CNS infection, coagulopathy, COVID-19, encephalitis, neuroinflammation, renin-angiotensin system, viral encephalopathy