中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (5): 352-358.

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

Long-term anodal block stimulation at sacral anterior roots promoted recovery of neurogenic bladder function in a rabbit model of complete spinal cord injury

  

  • 收稿日期:2011-09-24 修回日期:2011-11-22 出版日期:2012-02-15 发布日期:2012-02-15

Long-term anodal block stimulation at sacral anterior roots promoted recovery of neurogenic bladder function in a rabbit model of complete spinal cord injury

Xiaoran Wang1, Qi Gao2, Xiaoyu Yang2, Weihua Wang1, Xinquan Gu1, Guifeng Liu3, Peng Yan2, Ge Gao4, Xin Yu5, Yongjie Wang5, Jihu Lian6, Chaoling Shi7, Yao Wang1, Li Fan1   

  1. 1  Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
    2  Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
    3  Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
    4  Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
    5  Department of Critical Care Medicine, People’s Hospital of Jilin Province, Changchun 130021, Jilin Province, China
    6  Department of Urology, Jilin Provincial Hospital, Changchun 130021, Jilin Province, China
    7  Department of Urology, the Fourth Hospital of Jilin University, Changchun 130011, Jilin Province, China
  • Received:2011-09-24 Revised:2011-11-22 Online:2012-02-15 Published:2012-02-15
  • Contact: Xiaoyu Yang, Professor, Doctoral supervisor, Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; Xinquan Gu, Professor, Master’s supervisor, Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; Weihua Wang, Professor, Doctoral supervisor, Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China yangxiaoyu88@sina.com;Guxinq1213@sohu.com;wei@uro.med.tohoku.ac.jp
  • About author:Xiaoran Wang☆, Studying for doctorate, Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China Xiaoran Wang and Qi Gao contributed equally to this work.

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Abstract:

A complete spinal cord injury model was established in experimental rabbits using the spinal cord clip compression method. Urodynamic examination was performed 2 weeks later to determine neurogenic bladder status. The rabbits were treated with anodal block stimulation at sacral anterior roots for 4 weeks. Electrical stimulation of sacral anterior roots improved urodynamic parameters of neurogenic bladder in rabbit models of complete spinal cord injury, effectively promoted urinary function, and relieved urinary retention. Immunohistochemistry results showed that a balance was achieved among expression of muscarinic receptor subunits M2, M3, ATP-gated ion channel P2X3 receptors, and β2-adrenergic receptor, and nerve growth factor expression decreased. These results suggested that long-term sacral anterior root stimulation of anodal block could be used to treat neurogenic bladder in a rabbit model of complete spinal cord injury.

Key words: anode block, electrical stimulation, immunohistochemistry, neurogenic bladder, urodynamics, spinal cord injury