中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (5): 386-391.

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

Neural plasticity after spinal cord injury

  

  • 收稿日期:2011-11-24 修回日期:2012-01-10 出版日期:2012-02-15 发布日期:2012-02-15

Neural plasticity after spinal cord injury

Jian Liu, Xiaoyu Yang, Lianying Jiang, Chunxin Wang, Maoguang Yang   

  1. Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China
  • Received:2011-11-24 Revised:2012-01-10 Online:2012-02-15 Published:2012-02-15
  • Contact: Xiaoyu Yang, Professor, Doctoral supervisor, Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China yangxiaoyu88@sina.com
  • About author:Jian Liu☆, Studying for doctorate, Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China

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Abstract:

Plasticity changes of uninjured nerves can result in a novel neural circuit after spinal cord injury, which can restore sensory and motor functions to different degrees. Although processes of neural plasticity have been studied, the mechanism and treatment to effectively improve neural plasticity changes remain controversial. The present study reviewed studies regarding plasticity of the central nervous system and methods for promoting plasticity to improve repair of injured central nerves. The results showed that synaptic reorganization, axonal sprouting, and neurogenesis are critical factors for neural circuit reconstruction. Directed functional exercise, neurotrophic factor and transplantation of nerve-derived and non-nerve-derived tissues and cells can effectively ameliorate functional disturbances caused by spinal cord injury and improve quality of life for patients.

Key words: spinal cord injury, plasticity, synapse, functional exercise, neurotrophic factor, cell transplantation, tissue transplantation, reviews