中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (11): 2425-2426.doi: 10.4103/1673-5374.338994

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

脊椎动物之外:文昌鱼作为探索神经肌肉突触形成、组织和再生的相关模型系统

  

  • 出版日期:2022-11-15 发布日期:2022-04-22

Beyond vertebrates: the amphioxus as a relevant model system to explore the formation, organization, and regeneration of neuromuscular synapses

Esperanza Martínez, Sylvain Marcellini, Juan Pablo Henríquez*   

  1. Neuromuscular Studies Lab (NeSt Lab), Concepción, Chile (Martínez E, Henríquez JP)
    Laboratory of Development and Evolution (LADE), Concepción, Chile (Marcellini S)
    Group for the Study of Developmental Processes (GDeP), Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile (Martínez E, Marcellini S, Henríquez JP)
  • Online:2022-11-15 Published:2022-04-22
  • Contact: Dr. Juan Pablo Henríquez,jhenriquez@udec.cl.
  • Supported by:
    Our collaborative research was funded by VRID UdeC Nr 2021000233INV (to JPH) and Fondecyt 1190926 (to SM).

摘要: https://orcid.org/0000-0003-0820-7359 (Juan Pablo Henríquez)

Abstract: The neuromuscular junction (NMJ) is the peripheral synapse controlling muscle contraction and coordinated movement in a wide variety of animals. In humans, the mature NMJ is the primary target of morphological disassembly and functional decline in several physiological and pathological conditions, such as aging and motor diseases, respectively. Different paradigms of nerve damage in murine models have revealed that the peripheral nervous system bears regenerative abilities leading to functional NMJ recovery; however, this process is often inefficient in humans, likely due to their larger size and differences in the establishment of a still elusive regenerative niche at the NMJ (Zelada et al., 2021). One way to approach this obstacle is to understand the evolution of synaptic contacts, as they can provide novel insights into the fundamental cellular and molecular requirements that were ancestrally involved in the development and regeneration of neuromuscular synapses. Indeed, relevant information on the molecular mechanisms involved in peripheral neural organization and regeneration has been obtained from flies and worms (Richardson and Shen, 2019). The cephalochordates, also known as amphioxus, are a group of non-vertebrate chordate marine animals sharing many genomic and developmental features with the vertebrates. Interestingly, they also share several, although simplified, anatomical structures with vertebrates, including nervous and muscle tissues. Here, we specifically describe the distinctive neuromuscular contacts in amphioxus and briefly discuss how these features could provide valuable information to promote efficient vertebrate NMJ repair.